RT Journal
A1 Barbazuk, W. Bradley
A1 Korf, Ian
A1 Kadavi, Candy
A1 Heyen, Joshua
A1 Tate, Stephanie
A1 Wun, Edmund
A1 Bedell, Joseph A.
A1 McPherson, John D.
A1 Johnson, Stephen L.
T1 The Syntenic Relationship of the Zebrafish and Human Genomes
JF Genome Research 
JO Genome Research 
YR 2000 
FD September 01 
VO 10 
IS 9 
SP 1351 
OP 1358 
DO 10.1101/gr.144700 
UL http://genome.cshlp.org/content/10/9/1351.abstract 
AB The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.