@article{Dubchak01092000,
author = {Dubchak, Inna and Brudno, Michael and Loots, Gabriela G. and Pachter, Lior and Mayor, Chris and Rubin, Edward M. and Frazer, Kelly A.}, 
title = {Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons},
volume = {10}, 
number = {9}, 
pages = {1304-1306}, 
year = {2000}, 
doi = {10.1101/gr.142200}, 
abstract ={Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]}, 
URL = {http://genome.cshlp.org/content/10/9/1304.abstract}, 
eprint = {http://genome.cshlp.org/content/10/9/1304.full.pdf+html}, 
journal = {Genome Research} 
}