TY  - JOUR
A1  - Bolshoy, Alexander
A1  - Nevo, Eviatar
T1  - Ecologic Genomics of DNA: Upstream Bending in Prokaryotic Promoters
Y1  - 2000/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1185 
EP  - 1193 
DO  - 10.1101/gr.10.8.1185 
VL  - 10 
IS  - 8 
UR  - http://genome.cshlp.org/content/10/8/1185.abstract 
N2  - After our analysis of the distribution of predicted intrinsic curvature along all available complete prokaryotic genomes, the genomes were divided into two groups. Curvature distribution in all prokaryotes of the first group indicated a substantial fraction of promoters characterized by intrinsic DNA curvature located within or upstream of the promoter region. We did not find this peculiar DNA curvature distribution in prokaryotes in the second group. Remarkably, all bacteria of the first group were mesophilic, whereas many prokaryotes of the second group were hyperthermophilic. We hypothesize that DNA curvature plays a biologic role in gene regulation in mesophilic as opposed to hyperthermophilic prokaryotes, i.e., DNA curvature presumably has a functional adaptive significance determined by temperature selection. 
ER  -