TY  - JOUR
A1  - Batzoglou, Serafim
A1  - Pachter, Lior
A1  - Mesirov, Jill P.
A1  - Berger, Bonnie
A1  - Lander, Eric S.
T1  - Human and Mouse Gene Structure: Comparative Analysis and Application to Exon Prediction
Y1  - 2000/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 950 
EP  - 958 
DO  - 10.1101/gr.10.7.950 
VL  - 10 
IS  - 7 
UR  - http://genome.cshlp.org/content/10/7/950.abstract 
N2  - We describe a novel analytical approach to gene recognition based on cross-species comparison. We first undertook a comparison of orthologous genomic loci from human and mouse, studying the extent of similarity in the number, size and sequence of exons and introns. We then developed an approach for recognizing genes within such orthologous regions by first aligning the regions using an iterative global alignment system and then identifying genes based on conservation of exonic features at aligned positions in both species. The alignment and gene recognition are performed by new programs calledGLASS and ROSETTA, respectively.ROSETTA performed well at exact identification of coding exons in 117 orthologous pairs tested. 
ER  -