RT Journal
A1 Vergnaud, Gilles
A1 Denoeud, France
T1 Minisatellites: Mutability and Genome Architecture
JF Genome Research 
JO Genome Research 
YR 2000 
FD July 01 
VO 10 
IS 7 
SP 899 
OP 907 
DO 10.1101/gr.10.7.899 
UL http://genome.cshlp.org/content/10/7/899.abstract 
AB Minisatellites have been found in association with important features of human genome biology such as gene regulation, chromosomal fragile sites, and imprinting. Our knowledge of minisatellite biology has greatly increased in the past 10 years owing to the identification and careful analysis of human hypermutable minisatellites, experimental models in yeast, and recent in vitro studies of minisatellite recombination properties. In parallel, minisatellites have been put forward as potential biomarkers for the monitoring of genotoxic agents such as ionizing radiation. We summarize and discuss recent observations on minisatellites. In addition we take advantage of recent whole chromosome sequence data releases to provide a unifying view which may facilitate the annotation of tandem repeat sequences.