@article{Mallon01062000,
author = {Mallon, A.-M. and Platzer, M. and Bate, R. and Gloeckner, G. and Botcherby, M.R.M. and Nordsiek, G. and Strivens, M.A. and Kioschis, P. and Dangel, A. and Cunningham, D. and Straw, R.N.A. and Weston, P. and Gilbert, M. and Fernando, S. and Goodall, K. and Hunter, G. and Greystrong, J.S. and Clarke, D. and Kimberley, C. and Goerdes, M. and Blechschmidt, K. and Rump, A. and Hinzmann, B. and Mundy, C.R. and Miller, W. and Poustka, A. and Herman, G.E. and Rhodes, M. and Denny, P. and Rosenthal, A. and Brown, S.D.M.}, 
title = {Comparative Genome Sequence Analysis of the Bpa/Str Region in Mouse and Man},
volume = {10}, 
number = {6}, 
pages = {758-775}, 
year = {2000}, 
doi = {10.1101/gr.10.6.758}, 
abstract ={The progress of human and mouse genome sequencing programs presages the possibility of systematic cross-species comparison of the two genomes as a powerful tool for gene and regulatory element identification. As the opportunities to perform comparative sequence analysis emerge, it is important to develop parameters for such analyses and to examine the outcomes of cross-species comparison. Our analysis used gene prediction and a database search of 430 kb of genomic sequence covering the Bpa/Str region of the mouse X chromosome, and 745 kb of genomic sequence from the homologous human X chromosome region. We identified 11 genes in mouse and 13 genes and two pseudogenes in human. In addition, we compared the mouse and human sequences using pairwise alignment and searches for evolutionary conserved regions (ECRs) exceeding a defined threshold of sequence identity. This approach aided the identification of at least four further putative conserved genes in the region. Comparative sequencing revealed that this region is a mosaic in evolutionary terms, with considerably more rearrangement between the two species than realized previously from comparative mapping studies. Surprisingly, this region showed an extremely high LINE and low SINE content, low G+C content, and yet a relatively high gene density, in contrast to the low gene density usually associated with such regions.[The sequence data described in this paper have been submitted to EMBL under the following accession nos.: Mouse Genomic Sequence: Mouse contig A (AL021127), Mouse contig B (AL049866), BAC41M10 (AL136328), PAC303O11(AL136329). Human Genomic Sequence: Human contig 1 (U82671, U82670), Human contig 2 (U82695).]}, 
URL = {http://genome.cshlp.org/content/10/6/758.abstract}, 
eprint = {http://genome.cshlp.org/content/10/6/758.full.pdf+html}, 
journal = {Genome Research} 
}