TY  - JOUR
A1  - Pickeral, Oxana K.
A1  - Makałowski, Wojciech
A1  - Boguski, Mark S.
A1  - Boeke, Jef D.
T1  - Frequent Human Genomic DNA Transduction Driven by LINE-1 Retrotransposition
Y1  - 2000/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 411 
EP  - 415 
DO  - 10.1101/gr.10.4.411 
VL  - 10 
IS  - 4 
UR  - http://genome.cshlp.org/content/10/4/411.abstract 
N2  - Human L1 retrotransposons can produce DNA transduction events in which unique DNA segments downstream of L1 elements are mobilized as part of aberrant retrotransposition events. That L1s are capable of carrying out such a reaction in tissue culture cells was elegantly demonstrated. Using bioinformatic approaches to analyze the structures of L1 element target site duplications and flanking sequence features, we provide evidence suggesting that ∼15% of full-length L1 elements bear evidence of flanking DNA segment transduction. Extrapolating these findings to the 600,000 copies of L1 in the genome, we predict that the amount of DNA transduced by L1 represents ∼1% of the genome, a fraction comparable with that occupied by exons. 
ER  -