RT Journal
A1 Farnir, Frédéric
A1 Coppieters, Wouter
A1 Arranz, Juan-José
A1 Berzi, Paulette
A1 Cambisano, Nadine
A1 Grisart, Bernard
A1 Karim, Latifa
A1 Marcq, Fabienne
A1 Moreau, Laurence
A1 Mni, Myriam
A1 Nezer, Carine
A1 Simon, Patricia
A1 Vanmanshoven, Pascal
A1 Wagenaar, Danny
A1 Georges, Michel
T1 Extensive Genome-wide Linkage Disequilibrium in Cattle
JF Genome Research 
JO Genome Research 
YR 2000 
FD February 01 
VO 10 
IS 2 
SP 220 
OP 227 
DO 10.1101/gr.10.2.220 
UL http://genome.cshlp.org/content/10/2/220.abstract 
AB A genome-wide linkage disequilibrium (LD) map was generated using microsatellite genotypes (284 autosomal microsatellite loci) of 581 gametes sampled from the dutch black-and-white dairy cattle population. LD was measured between all marker pairs, both syntenic and nonsyntenic. Analysis of syntenic pairs revealed surprisingly high levels of LD that, although more pronounced for closely linked marker pairs, extended over several tens of centimorgan. In addition, significant gametic associations were also shown to be very common between nonsyntenic loci. Simulations using the known genealogies of the studied sample indicate that random drift alone is likely to account for most of the observed disequilibrium. No clear evidence was obtained for a direct effect of selection (“Bulmer effect”). The observation of long range disequilibrium between syntenic loci using low-density marker maps indicates that LD mapping has the potential to be very effective in livestock populations. The frequent occurrence of gametic associations between nonsyntenic loci, however, encourages the combined use of linkage and linkage disequilibrium methods to avoid false positive results when mapping genes in livestock.