TY  - JOUR
A1  - Farnir, Frédéric
A1  - Coppieters, Wouter
A1  - Arranz, Juan-José
A1  - Berzi, Paulette
A1  - Cambisano, Nadine
A1  - Grisart, Bernard
A1  - Karim, Latifa
A1  - Marcq, Fabienne
A1  - Moreau, Laurence
A1  - Mni, Myriam
A1  - Nezer, Carine
A1  - Simon, Patricia
A1  - Vanmanshoven, Pascal
A1  - Wagenaar, Danny
A1  - Georges, Michel
T1  - Extensive Genome-wide Linkage Disequilibrium in Cattle
Y1  - 2000/02/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 220 
EP  - 227 
DO  - 10.1101/gr.10.2.220 
VL  - 10 
IS  - 2 
UR  - http://genome.cshlp.org/content/10/2/220.abstract 
N2  - A genome-wide linkage disequilibrium (LD) map was generated using microsatellite genotypes (284 autosomal microsatellite loci) of 581 gametes sampled from the dutch black-and-white dairy cattle population. LD was measured between all marker pairs, both syntenic and nonsyntenic. Analysis of syntenic pairs revealed surprisingly high levels of LD that, although more pronounced for closely linked marker pairs, extended over several tens of centimorgan. In addition, significant gametic associations were also shown to be very common between nonsyntenic loci. Simulations using the known genealogies of the studied sample indicate that random drift alone is likely to account for most of the observed disequilibrium. No clear evidence was obtained for a direct effect of selection (“Bulmer effect”). The observation of long range disequilibrium between syntenic loci using low-density marker maps indicates that LD mapping has the potential to be very effective in livestock populations. The frequent occurrence of gametic associations between nonsyntenic loci, however, encourages the combined use of linkage and linkage disequilibrium methods to avoid false positive results when mapping genes in livestock. 
ER  -