TY  - JOUR
A1  - Gaudieri, Silvana
A1  - Dawkins, Roger L.
A1  - Habara, Kaori
A1  - Kulski, Jerzy K.
A1  - Gojobori, Takashi
T1  - SNP Profile within the Human Major Histocompatibility Complex Reveals an Extreme and Interrupted Level of Nucleotide Diversity
Y1  - 2000/10/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1579 
EP  - 1586 
DO  - 10.1101/gr.127200 
VL  - 10 
IS  - 10 
UR  - http://genome.cshlp.org/content/10/10/1579.abstract 
N2  - The human major histocompatibility complex (MHC) is characterized by polymorphic multicopy gene families, such as HLA and MIC (PERB11); duplications; insertions and deletions (indels); and uneven rates of recombination. Polymorphisms at the antigen recognition sites of the HLA class I and II genes and at associated neutral sites have been attributed to balancing selection and a hitchhiking effect, respectively. We, and others, have previously shown that nucleotide diversity between MHC haplotypes at non-HLA sites is unusually high (>10%) and up to several times greater than elsewhere in the genome (0.08%–0.2%). We report here the most extensive analysis of nucleotide diversity within a continuous sequence in the genome. We constructed a single nucleotide polymorphism (SNP) profile that reveals a pattern of extreme but interrupted levels of nucleotide diversity by comparing a continuous sequence within haplotypes in three genomic subregions of the MHC. A comparison of several haplotypes within one of the genomic subregions containing the HLA-B and -C loci suggests that positive selection is operating over the whole subgenomic region, including HLA and non-HLA genes.[The sequence data for the multiple haplotype comparisons within the class I region have been submitted to DDBJ/EMBL/GenBank under accession nos. AF029061, AF029062, and AB031005–AB031010. Additional sequence data have been submitted to the DDBJ data library under accession nos.AB031005–AB03101 and AF029061–AF029062.] 
ER  -