Figure 4.
(A) High weight submatrices of two and three genes in the lung adenocarcinoma data. (Black bars) Exclusive mutations; (gray bars) co-occurring mutations. Rows (patients) are ordered differently for each submatrix, to illustrate exclusivity and co-occurrence. (B) The location of gene sets in known pathways reveals that the triplet of genes codes for proteins in the mTOR signaling pathway (light gray nodes), and the pair (ATM, TP53) corresponds to interacting proteins in the cell cycle pathway (dark gray nodes). Interactions in the pathway are as reported in Ding et al. (2008).
