Comparing the human and chimpanzee genomes: Searching for needles in a haystack

Table 2.

Differences between humans and apes in incidence or severity of medical conditionsa


Medical condition

Humans

Great apes
Definite
   HIV progression to AIDS Common Very rare
   Hepatitis B/C late complications Moderate to severe Mild
   P. falciparum malaria Susceptible Resistant
   Myocardial infarction Common Very rare
   Endemic infectious retroviruses Rare Common
   Influenza A symptomatology Moderate to severe Mild
Probable
   Menopause Universal Rare?
   Alzheimer's disease pathology Complete No neurofibrillary tangles
   Epithelial cancers Common Rare?
   Atherosclerotic strokes Common Rare?
   Hydatiform molar pregnancy Common Rare?
Possible
   Rheumatoid arthritis Common Rare?
   Endometriosis Common Rare?
   Toxemia of pregnancy Common Rare?
   Early fetal wastage (aneuploidy) Common Rare?
   Bronchial asthma Common Rare?
   Autoimmune diseases Common Rare?
   Major psychoses
Common
Rare?
  • a See Varki 2000; Olson and Varki 2003, and references therein. This list excludes disease states explained by anatomical differences, e.g., difficult labor, varicose veins, spine disorders, hemorrhoids, hernias, etc.

This Article

  1. Genome Res. 15: 1746-1758

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