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A second-generation combined linkage–physical map of the human genome

¹ Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA; ² Affymetrix, Inc., Santa Clara, California 95051, USA; ³ Applied Biosystems, Inc., Foster City, California 94404, USA; ⁴ Illumina, Inc., San Diego, California 92121, USA; ⁵ Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48104, USA; ⁶ Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA

We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, along with confidence intervals, have been estimated for all map intervals. In addition, a regression-based smoothed map is provided that facilitates interpolation of positions of unmapped markers on this map. With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers.

⁸ Glaxo Smithkline, Research Triangle Park, NC 27709, USA;

⁹ Scripps Genomic Medicine, La Jolla, CA 92037, USA.

¹⁰ Corresponding author.

E-mail matise{at}biology.rutgers.edu; fax (732) 445-4972.

Article published online before print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.7156307

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